Neuroblastoma

A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Also Known As:

Neuroblastomas

Neoplasms: 1361496
- Neoplasms by Histologic Type: 2
  - Germ Cell and Embryonal Neoplasms: 4514
    - Neuroectodermal Tumors: 216
      - Neuroepithelial Neoplasms: 422
        Primitive Neuroectodermal Tumors: 1991
        Peripheral Primitive Neuroectodermal Tumors: 116
        Neuroblastoma: 26609
  - Glandular and Epithelial Neoplasms: 445
    - Neuroepithelial Neoplasms: 422
      - Primitive Neuroectodermal Tumors: 1991
        Peripheral Primitive Neuroectodermal Tumors: 116
        Neuroblastoma: 26609
  - Nerve Tissue Neoplasms: 1
    - Neuroectodermal Tumors: 216
      - Neuroepithelial Neoplasms: 422
        Primitive Neuroectodermal Tumors: 1991
        Peripheral Primitive Neuroectodermal Tumors: 116
        Neuroblastoma: 26609

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Disease

Drug/Important Bio-Agent (IBA)